Protein sorting and membrane-mediated interactions
نویسندگان
چکیده
منابع مشابه
Membrane composition-mediated protein-protein interactions.
The authors investigate membrane composition-mediated interactions between proteins adsorbed onto a two-component lipid bilayer close to critical demixing using coarse-grained molecular dynamics simulations and a phenomenological Ginzburg-Landau theory. The simulations consist of three-bead lipids and platelike proteins, which adsorb onto the membrane by binding preferentially to one of the two...
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We propose a computational framework to study the lipid-mediated clustering of integral membrane proteins. Our method employs a hierarchical approach. The potential of mean force (PMF) of two interacting proteins is computed under a coarse-grained 3-D model that successfully describes the structural properties of reconstituted lipid bilayers of dymiristoylphophatidylcholine (DMPC) molecules. Su...
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The amazing ability of living cells in achieving strict and robust control of their membrane morphologies and functions over different length scales leads to the concept that membrane domains, such as lipid rafts, are the basic organization units of cellular membranes. Yet fundamental understanding of the membrane-mediated interdomain interaction still remains incomplete. In the present work, w...
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The difficulty in growing crystals for x-ray diffraction analysis has hindered the determination of membrane protein structures. However, this is changing with the advent of a new method for growing high quality membrane protein crystals from the lipidic cubic phase. Although successful, the mechanism underlying this method has remained unclear. Here, we present a theoretical analysis of the pr...
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ژورنال
عنوان ژورنال: Biophysical Reviews
سال: 2012
ISSN: 1867-2450,1867-2469
DOI: 10.1007/s12551-012-0069-8